Additionally, IL-15 increases the expression of epithelial cell surface ligands, including major histocompatibility complex Class I polypeptide-related molecule A (MIC-A), which contributes to epithelial changes and other pathological processes associated with celiac disease including refractory celiac disease Type 2 and enteropathy-associated T-cell lymphoma (EATL) [12, 13]. This evidence concerns the gene MICA and enteropathy-associated T-cell lymphoma.