It is believed, therefore, that erythrocytic apoptosis could participate in the pathogenesis of clinical disorders in which enhanced levels of apoptotic RBC are a common feature, such as iron and glucose-6-phosphate dehydrogenase-(G6PD) deficiency, diabetes, renal insufficiency, hemolytic uremic syndrome, sickle-cell disease, sepsis and mycoplasma infection [2]. Here, G6PD is linked to sickle cell disease.