The potential mechanisms whereby high GL diets, over a period of years, could increase the risk of T2DM include an increase in insulin demand following hyperglycemia that, in turn, leads to a loss of pancreatic function (due to β-cell exhaustion or toxicity of hyperglycemia) and an increased insulin resistance induced by free fatty acids, produced in the late postprandial period by counterregulatory hormones. Here, INS is linked to Hyperglycemia.