Some carcinomas appear to hijack the stemness transcriptional factors’ machinery to support tumor-initiation, aberrant proliferation, and metastasis; accordingly, the activation of reprograming-like dedifferentiation mechanisms driven by master regulators of self-renewal and pluripotency (e.g., Sox2, Oct4, and Lin28) has been repeatedly shown to generate cell populations enriched with CSC-like cells that possess tumor-initiation and colonization capacities (64–72). Here, SOX2 is linked to neoplasm.