Alzheimer’s disease (AD), the most prevalent cause of dementia, is defined by two neuropathological hallmarks: senile plaques primarily composed of extracellular amyloid-beta (Aβ) deposits and intracellular neurofibrillary tangles (NFTs) comprised of hyper-phosphorylated tau protein. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.