TGFB1 and diabetic kidney disease: When podocytes are exposed to high glucose concentration in vitro, they demonstrate a clear upregulation of FSP1 (37). Urinary podocytes from diabetic nephropathy patients are FSP1+ (5). Moreover, ectopic overexpression of the known EMT inducer TGF-B1 in the glomerulus stimulates FSP1 in the podocyte (38)