IRAK1 and Alzheimer disease: To date confirmed targets of miRNA-146a include key AD-relevant members of the innate-immune system including the 155 kDa sialic-acid containing glycoprotein immune repressor complement factor H (CFH), the membrane spanning beta-amyloid precursor protein (βAPP)-associated TSPAN12, and the inflammation mediator interleukin receptor-associated kinase IRAK-1 (1).