Here, there was a tendency toward reduced [3H] MK-801 binding in the medial prefrontal cortex of Nrg1 HET mice which accords with the general view of NMDAR hypofunction in schizophrenia as well as research showing that NMDAR expression is reduced in the schizophrenia brain (Errico et al., 2013). This evidence concerns the gene NRG1 and schizophrenia.