MGMT and glioblastoma: There are experimental observations suggesting that inhibition of GST increases the response of glioblastoma cells to alkylating agents better than the inhibition of the enzyme O6-methylguanine-DNA methyltransferase (MGMT) (Juillerat-Jeanneret et al., 2008), the most frequently associated factor to temozolomide resistance in glioblastomas (Mrugala and Chamberlain, 2008).