As aspirin has been reported before to be an anti-diabetic agent (33), and as the compound is also described here to be an antihypertensive agent, aspirin might be the “compound of choice” to prevent atherosclerosis leading to AIHD, in that, none of the commonly used antihypertensive drugs (Table 1) unlike aspirin itself, was capable of stimulating insulin synthesis in the presence of glucose and NO which was generated by aspirin due to the activation of cNOS (19). Here, NOS3 is linked to atherosclerosis.