The role of LMW HA in the pathogenesis of inflammatory interstitial lung diseases leading to pulmonary fibrosis is still emerging; however, given that LFA-1 has been associated with the HA receptors CD44 and TLR2, we hypothesized that inhibition of LFA-1 could be exploited to treat inflammatory interstitial lung diseases leading to pulmonary fibrosis. The gene discussed is CD44; the disease is pulmonary fibrosis.