In order to clarify whether the mechanism by which NSC676914A is toxic in HEK293 cells is also responsible for killing cancer cells, parental HEK293 and OVCAR3 cells were pre-treated with 3 specific inhibitors: Caspase-mediated death (ZVAD), caspase-independent necroptosis (NEC-1), and ROS-mediated death (NAC), prior to treatment with NSC676914A or IKKβ inhibitor. This evidence concerns the gene PCSK1 and cancer.