RICTOR and Impaired glucose tolerance: On the other hand, inhibition of mTORC2 has been shown to negatively affect glucose regulation; deletion of Rictor in adipose tissue leads to weight gain and insulin resistance [38, 39], deletion of Rictor in liver leads to impaired glucose tolerance and increased gluco-neogenesis [6], and ubiquitous deletion of Rictor leads to hyperglycemia and hepatic insulin resistance [6].