Some of these include cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), retinal vasculopathy with cerebral leukodystrophies (RVCL), and collagen type IV, alpha 1 (COL4A1) and alpha 2 (COL4A2)‐related disorders. This evidence concerns the gene COL4A2 and Retinal vasculopathy and cerebral leukodystrophy.