The aim of the present study was therefore to examine the expression, clinicopathological correlates, and prognostic and treatment predictive ability of SATB1 and SATB2 in primary tumours (n = 175) and paired lymph node metastases (n = 105) from a consecutive cohort of patients with periampullary adenocarcinoma, including pancreatic cancer. Here, SATB1 is linked to familial pancreatic carcinoma.