Furthermore, we found that the autophagic level in MYCN non-amplified NB cells was hardly affected by GANT-61, but MYCN overexpression in MYCN non-amplified NB cells could enhance GANT-61 induced autophagy, suggesting that MYCN amplification has a positive role in the induction of the pro-survival autophagy. Here, MYCN is linked to neuroblastoma.