EZH2 and cancer: (6) IF down-regulate, through miR-mediated mechanisms, the lncRNA HOTAIR, which is often overexpressed in cancer cells and, in interaction with the polycomb-repressive complex 2 (PRC2, containing EZH2, among other proteins) and the HDM lysine specific demethylase 1 (LSD1) couples H3K27 trimethylation and H3K4 demethylation for epigenetic silencing of a multitude of genes.