EPHB2 and Familial prostate cancer: Vardi et al. investigated the demethylating properties of IF on EPHB2, a receptor tyrosine kinase commonly mutated in prostate cancer, RASSF1A (Ras Association Domain family 1, isoform A), a TSG involved in cell cycle arrest and frequently hypermethylated in prostate cancer, as well as on GSTP1 and BRCA1.