IL2 and autoimmune disease: Anti-inflammatory activity of IL-2 in autoimmunity has been generally accepted, since inherent defects in the IL-2 pathway, decreased response to IL-2, and/or reduced IL-2 availability, resulting in the impairment of Treg function, frequency and/or survival, have been found in many autoimmune disorders both in mice [3,4,5,6,7] and humans [8,9].