IL2 and autoimmune disease: In striking contrast are the doses of IL-2 used in therapy of autoimmune diseases; IL-2 single doses ranged from 0.33 × 106 to 4.5 × 106 IU [9,23,24,25,26], and the cumulative dose range of IL-2 was 1.65 × 106 to 100.2 × 106 IU [9,23,24,25,26].