The IAPs are highly expressed in a diverse array of tumors and are often associated with resistance to apoptosis and low sensitivity to chemotherapy drugs in some tumor types.1, 2, 3 Mutations and/or overexpression in EGFR that endow activated cell survival signaling have been regarded as a notorious cause of lung cancer and especially detected in almost half of NSCLC tumors. The gene discussed is EGFR; the disease is lung carcinoma.