HM90822B exhibited inhibitory effects on at least one subtype of IAP expression in each of the NSCLC cells tested; XIAP expression was decreased in H322, H522, PC-9 and HCC827 cells; survivin expression was decreased in A549, H322, H522, PC-9 and HCC827 cells; and cIAP1 expression was decreased in H322 and H522 cells. This evidence concerns the gene BIRC5 and non-small cell lung carcinoma.