HDAC8 and colonic neoplasm: Unlike MSC, SM is a poor substrate for aminotransferase activity.12 In a pilot study in vivo, we observed that dietary MSC, but not SM, inhibited mouse colon tumor multiplicity, and this was associated with increased Bmf expression and histone acetylation in the tumors, without marked changes in overall HDAC8 protein levels (Supplementary Figure 5).