MET and neoplasm: To detect if the c-Met+ fraction only will form a tumor xenograft tumor in immunodeficient mice, which is described as a major CSC characteristic,35 1 × 105 c-Methigh spheroidal and 1 × 106 cells c-Metlow adherent Pat-2, Pat-7 and Pat-8 cells were transplanted to the left flank and right flanks of 15 mice per cell line, respectively (Figure 5a).