SLC2A1 and precursor B-cell acute lymphoblastic leukemia: Pyruvate and lactate can be derived from non-glucose sources, such as glutamine, and this may account for maintenance of these metabolites even with reduced glucose metabolism.23 These data suggest that Glut1-dependent glucose mainly supports biosynthetic pathways in B-ALL cells, and reduced glucose uptake led to metabolic reprogramming to favor catabolism.