Treatment of Glut1fl/fl/Ubi-Cre-ERT2 B-ALL with 4-OHT led to efficient deletion of Glut1 with minimal compensation from other Glut transporters, and 4-OHT had no effect on control B-ALL cells (Figures 1c and d, Supplementary Figure 2). This evidence concerns the gene MAPK3 and precursor B-cell acute lymphoblastic leukemia.