It has been reported that decreased protein glycosylation upon glucose deprivation or 2-DG can lead to endoplasmic reticulum stress,11,30 which may promote Bim induction through the transcription factor CHOP.24,31 However, Glut1 deficiency only imposed mild, if any, ER stress to B-ALL cells. This evidence concerns the gene DDIT3 and acute lymphoblastic leukemia.