Similarly, Glut1 deficiency suppressed breast cancer progression.32 Other glycolytic enzymes have also been shown to have key-limiting roles in cancer metabolism, including pyruvate kinase M2,33 phospho-fructokinase,34 and lactate dehydrogenase A.35 Our data support Glut1 as an additional potential restriction point in cancer metabolism. The gene discussed is SLC2A1; the disease is breast cancer.