We believe Col10a1 trans-activators are promoters of chondrocyte hypertrophy and are targets for low bone growth as seen in skeletal dysplasia, whereas repressors will decrease Col10a1 expression and delay chondrocyte hypertrophy and are, therefore, targets for bone over growth as seen in osteophyte formation in osteoarthritis. This evidence concerns the gene COL10A1 and skeletal dysplasia.