Additionally, nuclear localisation of β-catenin is a characteristic of stem-like cell populations in cancers that are capable of initiating tumour formation.47 Our data revealed that silenced TIP30 expression accompanied by AKT and GSK-3β phosphorylation attenuated the phosphorylated β-catenin level and led to nuclear accumulation of β-catenin. This evidence concerns the gene HTATIP2 and cancer.