STAT3 and neoplasm: TIP30 is downregulated in several human tumours,15,17,18,22 and TIP30 overexpression may increase the sensitivity of HCC cells to chemotherapeutic drugs such as 5-FU.18 Sorafenib may regulate TIP30 expression to inhibit tumour metastasis through the Jun-activated kinase and signal transducer and activator of transcription 3 signalling pathways.23 We measured TIP30 expression in DSCs.