A previous report suggested that loss of TIP30 improves EGFR activity, which leads to upregulated p-AKT and pERK1/2 in human lung adenocarcinoma and mammary tumours.28,29 p-AKT phosphorylates GSK3β to regulate activation of β-catenin.45,46β-Catenin is a multifunctional protein with a central role in various diseases including cancer, and abnormal activation of β-catenin signalling is related to drug resistance. The gene discussed is AKT1; the disease is breast cancer.