CASP3 and colon adenocarcinoma: It is well known that caspase 3 (casp-3) as an executioner is essential in apoptosis.14 Interestingly, the apoptosis hallmark casp-3 cleavage did not occur in RT4 cells and COLO-205 colon adenocarcinoma cells treated with ART, while casp-3 is activated in ART-treated HeLa cells (Supplementary Figure S1).