TNFSF10 and cancer: ROS has a major role as a mediator of apoptosis33,34 and is known to be involved in TRAIL sensitization through the upregulation of DR5 by cancer chemopreventive agents.17,18 In the current study, Med induced generation of mitochondrial ROS and ROS mediated upregulation of DR5 in agreement with previous studies.33, 34, 35, 36 We found that quenching ROS by antioxidants abolished Med-induced potentiation of TRAIL-induced apoptosis indicating the critical role of ROS in modulation of TRAIL receptor DR5.