Treatments with either Med or TRAIL alone did not induce significant apoptosis in these cells, consistent with the earlier reports that myeloid leukemia cells being resistant to TRAIL-induced apoptosis.10,11 However, the concomitant treatment of Med and TRAIL to cells induced massive apoptosis in a time-dependent manner (Figure 2a, Upper and Lower Panel, Supplementary Figure S2). The gene discussed is TNFSF10; the disease is myeloid leukemia.