Recently, it was shown that the forced expression of Ascl1, Brn2 and Ngn2 in glioma cells can convert them into neurons with an efficiency of 20–40%.23 With a different and simpler combination of factors, our current study demonstrates that the efficiency could be significantly improved, with 95% of virus-infected human glioma cells converted to neuron-like cells. This evidence concerns the gene POU3F2 and glioma.