Nevertheless, the Kv1.3 inhibitor margatoxin decreased TNFα secretion by white adipose tissue from genetically obese (ob/ob) mice (Xu et al., 2004), and administration of the highly selective Kv1.3 inhibitor ShK-186 for 45 days to mice fed on an obesity-inducing diet reduced TNFα mRNA in visceral adipose tissue (Upadhyay et al., 2013). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.