Expression level alteration/sequestration of RNA-processing factors such as RRM-containing splicing factors (hnRNPs, SRSFs) further leads to large splicing alterations in SMA 123–125, TDP-43/FUS-related ALS 182,184–189 and C9ORF72-related ALS [153,154]. Here, SMN1 is linked to amyotrophic lateral sclerosis.