When considering5-azacytidine as a potential drug for the treatment of NMD-related disorders, it must also beconsidered that MYC represents a potent oncogene that is upregulated in many forms of cancer (Yokotaet al, 1986) and which can inducetumor formation in transgenic animals (Langenau et al, 2003; Shachaf et al, 2004). This evidence concerns the gene MYC and cancer.