VEGFA and age-related macular degeneration: Moreover, it has been proposed that the pan-VEGF blockade, especially the VEGF121 blockade, may be responsible for increasing the GA for AMD, thereby resulting in a poor visual prognosis.23–26 In a recent report, that evaluated the 7-year outcomes for ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON databases, macular atrophy was detected by fundus autofluorescence in 98% of the eyes, with a mean area26 of 9.4 mm2.