To develop both a broader and more detailed picture of the function of the IL-4Rα on macrophages during nematode infection, we recently performed an in-depth RNAseq analysis of IL-4Rα-deficient and -sufficient macrophages elicited by implantation of the peritoneal cavity with the nematode B. malayi or exposure to thioglycollate 9. Here, IL4R is linked to Nematoda infectious disease.