Restoration of Beclin-1 and autophagy in MCF-7 cells is associated with inhibition of MCF-7-induced tumorigenesis in nude mice [54]. BECN1+/− mice do not have increased incidence of mammary tumors but rather are susceptible to lymphomas and carcinomas of the lung and liver after long latency. The gene discussed is BECN1; the disease is carcinoma.