AKT1 and breast carcinoma: Studies of Kadota et al. [46] and Kim et al. [47] showed that the more advanced stages of breast cancer overexpress several other oncogenic and signaling proteins, such as IGF-1R, Cyclin D1, c-myc, pERK, Stat3, and Pak4, some of which are known activators of Akt-mTOR pathway.