Further evidence for active WNT signaling in lung fibrosis came from microarray analysis of IPF lungs, confirming enrichment of WNT-related genes encompassing ligands (WNT2, WNT5a), receptors (FZ7, FZ10), antagonists (SFRP1), and target genes (LEF1) [13]. Here, SFRP1 is linked to idiopathic pulmonary fibrosis.