The PF4 and CTAP-III contents were found to be decreased in patients with ND ALL (0.7506 ± 0.1003 μg/L, 599.55 ± 18.86 μg/L) and RR ALL (0.7246 ± 0.0972 μg/L, 578.31 ± 17.24 μg/L) in comparison with HCs (3.6872 ± 0.1853 μg/L, 1667.33 ± 49.36 μg/L) and CR ALL patients (3.6496 ± 0.1669 μg/L, 1687.48 ± 50.19 μg/L) (p = 1.4595E-5, p = 3.2170 E-5; p = 4.5269E-6, p = 3.7912 E-6). Here, PF4 is linked to acute lymphoblastic leukemia.