However, previous studies have indicated that cellular interaction with Col I is mediated largely through integrin α1β1, α2β1 and α3β1 receptors [25-27], and cross linking of integrin β1 could activate MMP-2 in ovarian carcinoma cells, suggesting direct involvement of integrin signaling in MMP-2 activation [21,28]. The gene discussed is MMP2; the disease is ovarian carcinoma.