In addition, MT1-MMP cooperates with β1-integrin during the migration of endothelial cells on various ECMs [16], and was found to colocalize with β1-integrin in actin-rich, “collagenolysis-free” leading edges of migrating fibrosarcoma and breast carcinoma cells grown on a 3D collagen matrix [49]. Here, MMP14 is linked to breast carcinoma.