Comparable to macCGI-58/ApoE-DKO mice (Fig. 6A), ASO-mediated knockdown of CGI-58 did not alter atherosclerosis burden in the aortic sinus (Fig. 7G) or thoracic aorta of LDLR−/− mice as measured by en face morphometry (Fig. 7H). Here, APOE is linked to atherosclerosis.