The immune parameters were consistent with primary agammaglobulinemia:IgG < 0.34 g/L (normal, 6–12 g/L), IgA <0.264 g/L (normal, 0.7-3 g/L), IgM 0.179 g/L (normal, 0.5-3 g/L), and the level of circulating CD19 + B-lymphocytes was dramatically reduced to 0.2%, (normal 5-15%, absolute count: 25 /mm3). The gene discussed is CD19; the disease is agammaglobulinemia.