JAG2 and cancer: For example, Yang and colleagues [39] determined in a murine model of Kras-induced lung adenocarcinoma that a subpopulation of metastasis-prone cancer cells were dependent on Jagged2 for their metastatic potential both in vitro and in vivo. Furthermore, they determined that Jagged2 drives metastasis through the downregulation of miR-200 [39].