CD28 and stroke disorder: Importantly, increased stroke size in the wild-type mice also translated into worse functional outcome as assessed by the grip test (values are the median with 25th and 75th percentiles, respectively, in brackets (control: 3.0 (2.0, 4.5); CD28 SA: 2.0 (0.0, 3.0), P<0.05), but not in the Bederson score (control: 2.0 (2.0, 3.0); CD28 SA: 3.0 (2.0, 4.0), P>0.05) (Figure 1B).