HLA-C and schizophrenia: Intriguingly, the discovery that MHC genes also have functions in brain development and in glutamate receptor signalling and synaptic plasticity (Fourgeaud et al., 2010; Lee et al., 2014) provides a potential link between MHC- and NMDAR-related aspects of the genetic aetiology of schizophrenia (McAllister, 2014).