TP53 and neoplasm: O-GlcNAcylation has been shown to play a critical role in carcinogenesis and cancer development through different mechanisms, especially by modulating the expression and/or activity of major oncogenic factors (MYC, p53, NF-κB, FOXM1), impacting tumor cell adhesion and migration by the regulation of the E-cadherin/β-catenin system, and by promoting the expression of metalloproteins [3, 6–10].