The data indicate that higher OGT and O-GlcNAcylation levels are related to enhanced grade of tumor aggressiveness, higher incidences of metastasis as well as poor prognosis in prostate, breast, endometrial, colorectal, pancreatic, ovarian, lung, bladder cancers and chronic lymphocytic leukemia cells [11, 14, 20–26]. The gene discussed is OGT; the disease is neoplasm.