Similar results were reported by Zhu et al. [20], who suggested that O-GlcNAcase level may be an independent prognostic factor for predicting tumor recurrence in hepatocellular carcinoma, and that O-GlcNAcylation plays an important role in migration, invasion of HCC cells through regulating E-cadherin and MMP expression. This evidence concerns the gene CDH1 and hepatocellular carcinoma.