ELN and supravalvular aortic stenosis: Thus, hemizygosity for the ELN gene is thought to cause the supravalvular aortic stenosis [4], LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition [3] and GTF2I hemizygosity is thought to contribute to the mental retardation in WS patients [5].