Three genes, CACNA1A, ATP1A2 and SCNA1A, have come from studies performed in individuals with familial hemiplegic migraine (FHM) a monogenic form of migraine with aura [7-9]; NGF, PGCP, PRDM16, TRPM8, and LRP1 are genes recently associated in Genome Wide Association Scan studies (GWAS) in common migraine populations [10]. The gene discussed is TRPM8; the disease is migraine disorder.