EGFR and cancer: Numerous instances of genes with recurrent ASE in cancer were attributed to recurrent genomic alterations involving known cancer genes, for example, TP53 and KRAS. We found a number of mutations with known or suspected roles in cancer, including L858R mutation in EGFR and several G12A and G12C mutations in KRAS, to exhibit overexpression of the mutant allele, highlighting potential ASE contribution to cancer phenotypes.