In addition, an inhibitory effect of 1,25(OH)2D3 on the differentiation of osteoclast precursors associated with a decreased RANK expression and an increased expression of the CCAAT enhancer-binding protein, an inhibitor of osteoclastogenesis on these cells has been proved in osteoclast precursors of normal peripheral blood and of synovial fluid of RA patients [58]. Here, TNFRSF11A is linked to rheumatoid arthritis.