As shown in Table 2 and Figure 2, there was no relevance of LIG4 T9I variants with overall cancer risk (homozygous: OR = 0.84, 95% CI = 0.55–1.27, P = 0.401; recessive: OR = 0.94, 95% CI = 0.81–1.09, P = 0.434; dominant: OR = 0.85, 95% CI = 0.58–1.25, P = 0.410; allele: OR = 0.93, 95% CI = 0.80–1.07, P = 0.306). This evidence concerns the gene LIG4 and cancer.