LIG4 and cancer: We found that there was no obvious relevance of LIG4 D501D variants with overall cancer risk (homozygous: OR = 0.97, 95% CI = 0.59–1.59, P = 0.907; recessive: OR = 0.96, 95% CI = 0.88–1.06, P = 0.434; dominant: OR = 0.99, 95% CI = 0.61–1.60, P = 0.952; allele: OR = 0.95, 95% CI = 0.87–1.03, P = 0.229) (Table 2).