Recently, some NOTCH2 mutations have been detected in some B-cell non-Hodgkin's lymphomas (B-NHLs) subtypes, such as DLBCLs [18] and marginal zone lymphomas (MZLs) [19], especially splenic marginal zone lymphomas (SMZLs, one subtype of MZLs) [20], [21]. This evidence concerns the gene NOTCH2 and B-cell non-Hodgkin lymphoma.