The western blotting results showed that in mt Notch2 DLBCL cells (including OCI-ly3 and Pfeiffer), the phosphorylation levels of P65 and IκBα were up-regulated significantly compared with those in wt Notch2 cells and pLVX cells, and in wt Notch2 DLBCL cells they were higher than pLVX cells (Fig. 6A). The gene discussed is RELA; the disease is diffuse large B-cell lymphoma.