Although the activation of truncate Notch2 on P50 was not as obvious as P65, the mRNA and protein levels of P50 in mt Notch2 DLBCL cells were up-regulated significantly in comparison to those in wt Notch2 cells and pLVX cells (Fig. 5B–5C). Here, NFKB1 is linked to diffuse large B-cell lymphoma.