In lung adenocarcinoma, CINDy specifically highlights modulatory interactions that affect epithelial proliferation, such as the direct phosphorylation by the Epidermal Growth Factor Receptor (EGFR) of the STAT1 [53] and STAT3 [54] TFs, a fundamental and well established step in the proliferative signal transduction cascade that was not detected by MINDy. This evidence concerns the gene STAT3 and lung adenocarcinoma.