IGF1R and small cell lung carcinoma: A Phase 1 dose-escalation study [70] of AMG-479 (ganitumab, a monoclonal antibody to IGF1R) or AMG-102 combined with platinum-based chemotherapy in untreated ED-SCLC showed an initial high incidence of venous thrombotic events (VTEs) in the AMG-102 cohorts and AMG-102 dose for phase II trial was set at 15 mg/kg and a carefully monitoring for TVE was recommended.